Endoscopic follow-up of gastric low-grade intraepithelial neoplasia and influencing factors for outcome

作者：Wanyin Deng, Ying Lin, Xiaolu Lin, Jinhui Zheng, Xiaoling Zheng, Shijie Yang, Xianbin Guo · 发表于：Zhonghua xiaohua neijing zazhi · 年份：2018 · DOI：10.3760/cma.j.issn.1007-5232.2018.12.006 · 被引用次数：1 · 研究领域：Gastric Cancer Management and Outcomes、Metastasis and carcinoma case studies

Objective To study the influencing factors for outcomes of gastric low-grade intraepithelial neoplasia (LGIN) for better LGIN treatment regimen. Methods Using magnifying endoscopy combined with narrow-band imaging (ME-NBI) follow-up strategy, the endoscopic features of 47 cases of LGIN in Fujian Provincial Hospital, including location, size, surface situation, demarcation line, microvascular pattern and microsurface pattern, were prospectively observed, then the factors influencing the outcome were analyzed. Results Among the 47 cases of LGIN, there were 35 cases in stable condition, whose results of biopsy and ME-NBI had no changes (stable LGIN), and the mean follow-up time was 20.7±6.9 months. The remaining 12 patients had progressive dysplasia (progressive LGIN), including 4 cases of high-grade intraepithelial neoplasia, and 8 cases of moderate dysplasia. The mean follow-up time was 16.3±11.8 months. There were no significant differences between the two groups in gender (P=0.33), mean age (P=0.13), lesion distribution (P=0.70), and lesion morphology (P=0.97). The lesion size was less than 20 mm in the stable group (71.4%, 25/35), and over 20 mm in the progressive group (66.7%, 8/12), and the difference was statistically significant (P=0.02). The proportion of the lesion surface heterogeneity in the progressive group was significantly higher than that in the stable group[75.0% (9/12) VS 34.3% (12/35), P=0.01]. The proportion of positive manifestations under ME-...