Recent outcomes of unexplained neonatal seizure: a retrospective study of clinical features in 47 cases

作者：Haoting Yu, Jianhua Fu, Xindong Xue · 发表于：International journal of pediatrics · 年份：2019 · DOI：10.3760/cma.j.issn.1673-4408.2019.11.016 · 研究领域：Neonatal and fetal brain pathology、Atomic and Subatomic Physics Research、EEG and Brain-Computer Interfaces

Objective To explore the relationship between features of neonatal seizure and recent outcomes of patients with unexplained neonatal seizure, which may provide evidence for early assessment of prognosis. Methods Forty-seven cases of unexplained neonatal seizure admitted to the Department of Neonatology in Shengjing Hospital of China Medical University from January 2014 to June 2018, were followed-up at the age of more than 6 months.According to the recent outcomes(recurrent seizures during non-neonatal period and levels of development when they were followed-up), the patients were divided into good recent outcomes group(34 cases)and poor recent outcomes group(13 cases). The general information, characteristics of seizure and EEG changes during neonatal period were analyzed retrospectively. Results There was no significant difference in gender, gestational age, birth weight, onset of first seizure, type of seizure, duration of seizure, and interval of seizures between two groups(P>0.05). There were 11 cases in poor recent outcomes group and 30 cases in good recent outcomes group that finished EEG.Compared with patients with good recent outcomes, patients with poor recent outcomes had significantly more abnormal EEG, paroxysmal abnormal changes and paroxysmal abnormal changes with abnormal background activity(90.9% vs.43.3%, 63.6% vs.10.0%, 36.4% vs.6.7%), with statistically significant difference(P<0.05). Thirty-nine cases with recurrent seizures during non-neonat...