Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer’s disease

作者：Denise Visser, Emma E. Wolters, Sander C.J. Verfaillie, Emma M. Coomans, Tessa Timmers, Hayel Tuncel, Juhan Reimand, Ronald Boellaard, Albert D. Windhorst, Philip Scheltens, Wiesje M. van der Flier, Rik Ossenkoppele, Bart N.M. van Berckel · 发表于：European Journal of Nuclear Medicine and Molecular Imaging · 年份：2020 · DOI：10.1007/s00259-020-04831-w · 被引用次数：55 · 研究领域：Dementia and Cognitive Impairment Research、Functional Brain Connectivity Studies、Alzheimer's disease research and treatments

Abstract Purpose We aimed to investigate associations between tau pathology and relative cerebral blood flow (rCBF), and their relationship with cognition in Alzheimer’s disease (AD), by using a single dynamic [ 18 F]flortaucipir positron emission tomography (PET) scan. Methods Seventy-one subjects with AD (66 ± 8 years, mini-mental state examination (MMSE) 23 ± 4) underwent a dynamic 130-min [ 18 F]flortaucipir PET scan. Cognitive assessment consisted of composite scores of four cognitive domains. For tau pathology and rCBF, receptor parametric mapping (cerebellar gray matter reference region) was used to create uncorrected and partial volume-corrected parametric images of non-displaceable binding potential (BP ND ) and R 1 , respectively. (Voxel-wise) linear regressions were used to investigate associations between BP ND and/or R 1 and cognition . Results Higher [ 18 F]flortaucipir BP ND was associated with lower R 1 in the lateral temporal, parietal and occipital regions. Higher medial temporal BP ND was associated with worse memory, and higher lateral temporal BP ND with worse executive functioning and language. Higher parietal BP ND was associated with worse executive functioning, language and attention, and higher occipital BP ND with lower cognitive scores across all domains. Higher frontal BP ND was associated with worse executive function and attention. For [ 18 F]flortaucipir R 1 , lower values in the lateral temporal and parietal ROIs were associated with worse exe...