The clinical analysis of 60 cases of paraneoplastic neurological syndrome

作者：Yao Zhang, Lixin Zhou, Nan Zhi, Haitao Ren, Min Qian, Yi‐Cheng Zhu, Hongzhi Guan · 发表于：Chin J Neurol · 年份：2015 · DOI：10.3760/cma.j.issn.1006-7876.2015.10.012 · 研究领域：Autoimmune Neurological Disorders and Treatments、Genetic Neurodegenerative Diseases

Objective To explore the clinical features of paraneoplastic neurological syndrome (PNS). Methods Sixty PNS patients in Peking Union Medical College Hospital from January 2008 to December 2012 according to the international diagnostic criteria for PNS recommended by Graus were diagnosed and their clinical features were retrospectively analyzed. Results Sixty PNS patients had 11 different clinical syndromes, including 29/60 (48.3%) classical syndromes and 27/60 (45.0%) non-classical syndromes. The most common classical syndromes were limbic encephalitis (11/60, 18.3%) and subacute cerebellar degeneration (10/60, 16.7%), while the most common non-classical syndrome was subacute/chronic sensorimotor neuropathies. Thirty-three of sixty (55.0%) PNS patients were found with underlying tumors, the most common of which was lung cancer (13/33, 39.4%), and 46.2% (6/13) of lung cancer was small cell lung cancer. And 19/60 (31.7%) PNS patients had well characterized onconeuronal antibodies in their serum/cerebral spinal fluid, and anti-Hu and anti-Yo antibodies were most commonly seen (16/19). No partially characterized onconeuronal antibody was found. Eight of sixty (13.3%) patients were found with neuronal cell-surface antibodies, all of which were anti-N-methyl-D-aspartate receptor antibodies. Eleven of thirty-one followed-up patients died, including 7 (7/15) definite PNS and 4 (4/16) possible PNS, without significant difference between groups (χ2=0.782 P=0.380). The 1-, ...