Application value of MRI examination in the efficacy evaluation of infliximab combined with seton placement for perianal fistulizing Crohn′s disease and influencing factors analysis of deep remission

作者：Mengci Zhang, Lichao Qiao, Xin Zhu, Ping Zhu, Yunfei Gu, Jing Li, Bolin Yang, Hongjin Chen · 发表于：Zhōnghuá xiāohuà wàikē zázhì/Zhonghua xiaohua waike zazhi · 年份：2019 · DOI：10.3760/cma.j.issn.1673-9752.2019.03.015 · 研究领域：Anorectal Disease Treatments and Outcomes、Diverticular Disease and Complications、Inflammatory Bowel Disease

Objective To investigate the application value of magnetic resonance imaging (MRI) examination in the efficacy evaluation of infliximab combined with seton placement for perianal fistulizing Crohn′s disease (PFCD) and influencing factors of deep remission. Methods The retrospective case-control study was conducted. The clinicopathological data of 57 patients with PFCD who were admitted to the Affiliated Hospital of Nanjing University of Chinese Medicine from August 2010 to October 2017 were collected. There were 39 males and 18 females, aged (24±9)years, with a range of 14-58 years. Patients underwent MRI examination preoperatively and postoperatively. Observation indicators: (1) follow-up situations; (2) influencing factors analysis of deep remission of PFCD. Follow-up using outpatient and inpatient reexamination was performed to detect clinical recovery of patients up to October 2017. Measurement data with normal distribution were represented as Mean±SD. Measurement data with skewed distribution were described as M (range). Count data were represented as absolute number or percentage. The univariate analysis was performed using the chi-square test. The multivariate analysis was done using the logistic regression model, using P<0.15 as an inclusion criteria in the univariate analysis. Results (1) Follow-up situations: 57 patients with PFCD undergoing inflixmab combined with seton placement were followed up for (40±24)months. During the follow-up, 24 of 57 patien...