Modular design of theEnterococcus hiraemuramidase-2 andStreptococcus faecalisautolysin

作者：Bernard Joris, Serge Englebert, Chien-Peng Chu, Reiko Kariyama, L Daneo-Moore, Gerald D. Shockman, Jean‐Marie Ghuysen · 发表于：FEMS Microbiology Letters · 年份：1992 · DOI：10.1111/j.1574-6968.1992.tb05218.x · 被引用次数：117 · 研究领域：RNA and protein synthesis mechanisms、Enzyme Structure and Function、Bacterial Genetics and Biotechnology

The mature forms of the extracellular muramidase-2 of Enterococcus hirae and Streptococcus faecalis autolysin have very.similar primary structures.Each consists of an active-site-containing N-terminal domain fused to a multiple-repeat C-terminal domain.Polypeptide segments occurring at equivalent places in these two bacterial wall lytic enzymes have homologues in two phage lysozymes and in three functionally unrelated proteins, illustrating the principle that protein molecules frequently are constructed from modules that are linked in a single polypeptide chain.