Effect of unilateral basal ganglia hemorrhage on long-term behavioral development of neonatal rats

作者：Sun Dan, Junhua Xiao, Liu Zhi-sheng, Deng Xiaolong, Jiasheng Hu · 发表于：Zhonghua shiyong erke linchuang zazhi · 年份：2016 · DOI：10.3760/cma.j.issn.2095-428x.2016.24.010 · 研究领域：Neonatal and fetal brain pathology、Traumatic Brain Injury and Neurovascular Disturbances

Objective To investigate the effect of unilateral basal ganglia hemorrhage on long-term behavio-ral development of neonatal SD rats. Methods Forty-eight neonatal SD rats (10 days after birth) were equally divided into cerebral hemorrhage (CH) group, sham operation (SH) group and normal control (NC) group randomly, 16 cases for each group.Stereotaxic apparatus was used to inject autologous blood 25 μL into rats′ brain caudate nu-cleus to establish basal ganglia hemorrhage model, while SH group was injected with nothing, and NC group received no treatment.Berderson scoring method was used to test rats′ neurological functions on the first day, the third day, the seventh day, and the fourteenth day after operation, respectively.The open-field environment test and the Lat maze were used to assess behavior of the rats on the fourteenth day after operation, lasting for 3 days continuously. Results (1)After being modeled rats appeared with different degrees of neurological function damage.SH group rats′ neurological function damage was slight, which was completely restored in the 72 hours after surgery.CH group rats appeared hemiplegia and muscle tension change.CH rats neurological scores′ on the first and third day after modeling scores were separate (3.40±0.83) scores and (1.13±0.92) scores respectively, and the scores were statistically higher than SH group [(0.73±0.59) scores and (0.13±0.35) scores]and NC group (all P 0.05). (2)On the fourteenth day after modeling, i...