Introductions and early spread of SARS-CoV-2 in the New York City area

作者：Ana Silvia Gonzalez-Reiche, Matthew M. Hernandez, Mitchell J. Sullivan, Brianne Ciferri, Hala Hathlool Alshammary, Ajay Obla, Shelcie Fabre, Giulio Kleiner, José Polanco, Zenab Khan, Bremy Alburquerque, Adriana van de Guchte, Jayeeta Dutta, Nancy J. Francoeur, Betsaida Salom Melo, Irina A. Oussenko, Gintaras Y. Deikus, Juan Soto, Shwetha Hara Sridhar, Ying‐Chih Wang, Kathryn Twyman, Andrew Kasarskis, Deena R. Altman, Melissa Laird Smith, Robert Sebra, Judith A. Aberg, Florian Krammer, Adolfo García‐Sastre, Marta Łuksza, Gopi Patel, Alberto Paniz‐Mondolfi, Melissa Gitman, Emilia Mia Sordillo, Viviana R. Simon, Harm van Bakel · 发表于：Science · 年份：2020 · DOI：10.1126/science.abc1917 · 被引用次数：452 · 研究领域：COVID-19 epidemiological studies、Zoonotic diseases and public health、Data-Driven Disease Surveillance

New York City (NYC) has emerged as one of the epicenters of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. To identify the early transmission events underlying the rapid spread of the virus in the NYC metropolitan area, we sequenced the virus that causes coronavirus disease 2019 (COVID-19) in patients seeking care at the Mount Sinai Health System. Phylogenetic analysis of 84 distinct SARS-CoV-2 genomes indicates multiple, independent, but isolated introductions mainly from Europe and other parts of the United States. Moreover, we found evidence for community transmission of SARS-CoV-2 as suggested by clusters of related viruses found in patients living in different neighborhoods of the city.