Blocking immunosuppressive neutrophils deters pY696-EZH2–driven brain metastases

作者：Lin Zhang, Jun Yao, Yongkun Wei, Zhifen Zhou, Ping Li, Jingkun Qu, Akosua Badu-Nkansah, Xiangliang Yuan, Yu-Wen Huang, Kazutaka Fukumura, Xizeng Mao, Wei-Chao Chang, Jodi M. Saunus, Sunil R. Lakhani, Jason T. Huse, Mien‐Chie Hung, Dihua Yu · 发表于：Science Translational Medicine · 年份：2020 · DOI：10.1126/scitranslmed.aaz5387 · 被引用次数：123 · 研究领域：Epigenetics and DNA Methylation、Immune cells in cancer、Ferroptosis and cancer prognosis

immunosuppressive neutrophils into the brain to drive metastasis outgrowth. G-CSF-blocking antibodies or immune checkpoint blockade therapies combined with Src inhibitors impeded brain metastasis in multiple mouse models. These findings indicate that pY696-EZH2 can function as a methyltransferase-independent transcription factor to facilitate the brain infiltration of immunosuppressive neutrophils, which could be clinically targeted for brain metastasis treatment.