Relationship between interventricular septum thickness and renal function in patients with type 2 diabetes mellitus

作者：Haofei Hu, Jinghong Wei, Dehan Liao, Wen-Xiong Zhou, Cuimei Wei, Shilun Jiang, Qitao Xu, Fupeng Liao, Zihe Mo · 年份：2017 · DOI：10.3760/cma.j.issn.1001-7097.2017.11.002 · 研究领域：Chronic Kidney Disease and Diabetes

Objective To investigate the relationship between interventricular septum thickness(IVS) and renal function in patients with diabetes mellitus. Methods Two hundred and sixty-five patients of type 2 diabetes without dialysis were enrolled in a cross-sectional study. According to their IVS, the patients were divided into normal group (IVS≤11 mm) and higher IVS group (IVS>11 mm). All patients according to evaluated glomerular filtration rate (eGFR) level were divided into eGFR≥60 ml·min-1·(1.73 m2)-1 group and eGFR<60 ml·min-1·(1.73 m2)-1 group. The demographic characteristic, biochemical examination, eGFR, and proteinuria of different groups were compared. Pearson or spearman correlation was used to analyze the relationship between eGFR, IVS and other parameters. eGFR<60 ml·min-1·(1.73 m2)-1 and IVS thickening were analyzed by binary logistic regression. Risk factors affect the prognosis of renal function in patients with diabetes mellitus were analyzed by Cox regression analysis. Results Compared with normal group, patients in the higher IVS group had higher systolic pressure (P=0.002), their level of Scr, BUN, 24 h urinary protein were increased (all P<0.05), while the level of eGFR, albumin (ALB), hemoglobin (Hb) and fasting blood glucose were decreased (all P<0.05). The prevalence of hypertension was increased (81.16% vs 58.67%, χ2=11.273, P=0.001), and there was also a difference in the proportion of patients in each stage of CKD (χ2=34.593, P<0.001). Correlat...