Meta-analysis of the association between Trp64Arg polymorphism in β3-adrenergic receptor gene and overweight/obesity in children

作者：Jing Wu, Jiao Zhouyang, Jing Zhang, Qiang Luo, Yufeng Liu, Jindou An, Peichao Tian · 发表于：Zhonghua neifenmi daixie zazhi · 年份：2016 · DOI：10.3760/cma.j.issn.1000-6699.2016.02.008 · 研究领域：Adipose Tissue and Metabolism、Pharmacological Effects and Assays、Stress Responses and Cortisol

In this study, PubMed, Embase, China National Knowledge Infrastructure, databases VIP Chinese Periodical Database, and Wanfang Chinese Periodical Database were systematically searched for the case-control study related β3-adrenergic receptor(ADRB3) Trp64Arg gene polymorphism to overweight/obesity among children from 1962 to 2014. Twelve eligible studies with 2 222 overweight/obese children and 1 955 normal children were included according the uniform inclusion and exclusion criteria. Meta-analyses showed that Trp64Arg polymorphism was associated with significantly increased overweight/obesity risk in Arg carriers among children(OR=1.34, 95%CI 1.17-1.53). After stratification for ethnicity, highly significant coorelation of Trp64Arg polymorphism to overweight/obesity in Asian children(OR=1.44, 95%CI 1.23-1.68) but not significant in Europe(OR=1.05, 95%CI 0.79-1.40). It suggested that Trp64Arg polymorphism is associated with overweight/obesity susceptibility in children. Our results support an strong association between Trp64Arg polymorphism and overweight/obesity among the Asian children investigated. (Chin J Endocrinol Metab, 2016, 32: 121-124) Key words: β3-adrenergic receptor; Polymorphism; Children; Obesity; Meta-analysis