Low testosterone levels predict clinical adverse outcomes in SARS‐CoV‐2 pneumonia patients

作者：Giulia Rastrelli, Vincenza Di Stasi, Francesco Inglese, Massimiliano Beccaria, Martina Garuti, Domenica Di Costanzo, Fabio Spreafico, Graziana Francesca Greco, Giulia Cervi, Antonietta Pecoriello, Angela Magini, Tommaso Todisco, Sarah Cipriani, Elisa Maseroli, Giovanni Corona, Andrea Salonia, Andrea Lenzi, Mario Maggi, Giuseppe De Donno, Linda Vignozzi · 发表于：Andrology · 年份：2020 · DOI：10.1111/andr.12821 · 被引用次数：368 · 研究领域：Hormonal and reproductive studies、COVID-19 Impact on Reproduction、COVID-19 Clinical Research Studies

BACKGROUND: The pandemic of new severe acute respiratory syndrome (SARS) due to coronavirus (CoV) 2 (SARS-CoV-2) has stressed the importance of effective diagnostic and prognostic biomarkers of clinical worsening and mortality. Epidemiological data showing a differential impact of SARS-CoV-2 infection on women and men have suggested a potential role for testosterone (T) in determining gender disparity in the SARS-CoV-2 clinical outcomes. OBJECTIVES: To estimate the association between T level and SARS-CoV-2 clinical outcomes (defined as conditions requiring transfer to higher or lower intensity of care or death) in a cohort of patients admitted in the respiratory intensive care unit (RICU). MATERIALS AND METHODS: A consecutive series of 31 male patients affected by SARS-CoV-2 pneumonia and recovered in the respiratory intensive care unit (RICU) of the "Carlo Poma" Hospital in Mantua were analyzed. Several biochemical risk factors (ie, blood count and leukocyte formula, C-reactive protein (CRP), procalcitonin (PCT), lactate dehydrogenase (LDH), ferritin, D-dimer, fibrinogen, interleukin 6 (IL-6)) as well as total testosterone (TT), calculated free T (cFT), sex hormone-binding globulin (SHBG), and luteinizing hormone (LH) were determined. RESULTS: Lower TT and cFT were found in the transferred to ICU/deceased in RICU group vs groups of patients transferred to IM or maintained in the RICU in stable condition. Both TT and cFT showed a negative significant correlation with biochem...