PECAM-1 overexpression signifies aggressive biologic behavior of oral lichen planus – A pilot study

作者：A Lavanya, Wafa Khan, Preeti Singh, Dominic Augustine, RoopaS Rao, SV Sowmya, VanishriC Haragannavar, K. Shwetha Nambiar · 发表于：Indian Journal of Dental Research · 年份：2020 · DOI：10.4103/ijdr.ijdr_653_18 · 被引用次数：3 · 研究领域：Oral Health Pathology and Treatment、Salivary Gland Disorders and Functions、Cell Adhesion Molecules Research

CONTEXT: The etiopathogenesis of oral lichen planus (OLP) is still debatable. According to literature, many studies have illustrated OLP as a T-cell-mediated chronic autoimmune disease. Currently, there is increased evidence of chronic inflammation in OLP and its association with vascular adhesion molecules (VAMs). AIM: The aim of this study was to evaluate the expression of VAM (PECAM-1) in OLP. SETTING AND DESIGN: Tissue samples involved 20 archival cases of histopathologically confirmed OLP (n = 15) and normal mucosa (n = 5) as controls. MATERIALS AND METHODS: The sections were subjected to immunohistochemical analysis using antibody to PECAM-1. Brown staining of the endothelial cells of blood vessels was considered positive. The expression of PECAM-1 in OLP was statistically analyzed using Wilcoxon sign-rank test. RESULTS: The expression of PECAM-1 in OLP was statistically significant when compared with normal mucosa (P < 0.05). A statistically significant difference was also observed in PECAM-1 expression between the reticular type and erosive type of OLP. CONCLUSION: PECAM-1 was found to be overexpressed in OLP; difference in PECAM-1 expression was noted between the reticular and erosive types. The VAMs could be exploited as a possible therapeutic target in OLP to modulate the disease process thereby reducing the dependency on corticosteroids.