Cobalt-Catalyzed Asymmetric Cross-Coupling Reaction of Fluorinated Secondary Benzyl Bromides with Lithium Aryl Boronates/ZnBr2

作者：Weichen Huang, Xiaolong Wan, Qilong Shen · 发表于：Organic Letters · 年份：2020 · DOI：10.1021/acs.orglett.0c01363 · 被引用次数：45 · 研究领域：Fluorine in Organic Chemistry、Catalytic C–H Functionalization Methods、Cyclopropane Reaction Mechanisms

A cobalt-catalyzed asymmetric cross-coupling of α-bromo-α-fluorotoluene derivatives with a variety of aryl zincates derived from lithium aryl n -butyl pinacol boronates and ZnBr 2 under mild reaction conditions was described. In addition to mild reaction conditions, another advantage includes the compatibility of various common functional groups such as fluoride, chloride, bromide, cyano, or ester groups. Furthermore, this protocol was successfully applied to the enantioselective synthesis of three fluorinated derivatives of biologically active compounds or drug molecules.