DNA vaccine protection against SARS-CoV-2 in rhesus macaques

作者：Jingyou Yu, Lisa H. Tostanoski, Lauren E. Peter, Noe B. Mercado, Katherine McMahan, Shant H. Mahrokhian, Joseph P. Nkolola, Jinyan Liu, Zhenfeng Li, Abishek Chandrashekar, David R. Martinez, Carolin Loos, Caroline G. Atyeo, Stephanie Fischinger, John Stephen Burke, Matthew D. Slein, Yuezhou Chen, Adam Zuiani, Felipe Lelis, Meghan E. Travers, Shaghayegh Habibi, Laurent Pessaint, Alex Van Ry, Kelvin Blade, Renita Brown, Anthony Cook, Brad W. Finneyfrock, Alan Dodson, Elyse Teow, Jason Velasco, Roland C. Zahn, Frank Wegmann, Esther Apraku Bondzie, Gabriel Dagotto, Makda S. Gebre, Xuan He, Catherine Jacob-Dolan, Marinela Kirilova, Nicole E. Kordana, Zijin Lin, Lori F. Maxfield, Felix Nampanya, Ramya Nityanandam, John D. Ventura, Huahua Wan, Yongfei Cai, Bing Chen, Aaron G. Schmidt, Duane R. Wesemann, Ralph Steven Baric, Galit Alter, Hanné Andersen, Mark G. Lewis, Dan H. Barouch · 发表于：Science · 年份：2020 · DOI：10.1126/science.abc6284 · 被引用次数：1128 · 研究领域：SARS-CoV-2 and COVID-19 Research、Immunotherapy and Immune Responses、Viral gastroenteritis research and epidemiology

Prototype DNA vaccines for SARS-CoV-2 The development of a vaccine to protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an urgent biomedical need. Yu et al. designed a series of prototype DNA vaccines against the SARS-CoV-2 spike protein, which is used by the virus to bind and invade human cells. Analysis of the vaccine candidates in rhesus macaques showed that animals developed protective humoral and cellular immune responses when challenged with the virus. Neutralizing antibody titers were also observed at levels similar to those seen in humans who have recovered from SARS-CoV-2 infection. Science , this issue p. 806