Biodegradable phosphorylcholine copolymer for cardiovascular stent coating

作者：Jun Liu, Jing Wang, Yunfan Xue, Tingting Chen, Danni Huang, Youxiang Wang, Ke‐feng Ren, Yunbing Wang, Guosheng Fu, Jian Ji · 发表于：Journal of Materials Chemistry B · 年份：2020 · DOI：10.1039/d0tb00813c · 被引用次数：38 · 研究领域：Polymer Surface Interaction Studies、Electrospun Nanofibers in Biomedical Applications、Infectious Aortic and Vascular Conditions

Phosphorylcholine (PC) based polymer coatings with excellent biocompatibility have shown successful commercialization in drug-eluting stents. However, poor degradability represents a challenge in the application of biodegradable stents. Herein, a biodegradable phosphorylcholine copolymer is developed based on one-step radical ring-opening polymerization (RROP). This copolymer was synthesized by copolymerization of a PC unit, degradable ester (2-methylene-1,3-dioxepane, MDO) unit and non-degradable butyl methacrylate (BMA) unit, which showed ratio controllability by changing the monomer ratio during polymerization. We demonstrated that the copolymer with the ratio of 34% MDO, 19% MPC and 47% BMA could form a stable coating by ultrasonic spray, and showed good blood compatibility, anti-adhesion properties, biodegradability, and rapamycin eluting capacity. In vivo study revealed its promising application as a biodegradable stent coating. This work provides a facile path to add biodegradability into PC based polymers for further bio-applications.