Association of clinical and radiographic findings with the outcomes of 93 patients with COVID-19 in Wuhan, China

作者：Lingli Li, Lian Yang, Shan Gui, Feng Pan, Tianhe Ye, Bo Liang, Hu Yu, Chuansheng Zheng · 发表于：Theranostics · 年份：2020 · DOI：10.7150/thno.46569 · 被引用次数：68 · 研究领域：COVID-19 Clinical Research Studies、COVID-19 diagnosis using AI、Long-Term Effects of COVID-19

To retrospectively analyze serial chest CT and clinical features in patients with coronavirus disease 2019 for the assessment of temporal changes and to investigate how the changes differ in survivors and nonsurvivors. Methods: The consecutive records of 93 patients with confirmed COVID-19 who were admitted to Wuhan Union Hospital from January 10, 2020, to February 22, 2020, were retrospectively reviewed. A series of chest CT findings and clinical data were collected and analyzed. The serial chest CT scans were scored on a semiquantitative basis according to the extent of pulmonary abnormalities. Chest CT scores in different periods (0 -5 days, 6 -10 days, 11 -15 days, 16 -20 days, and > 20 days) since symptom onset were compared between survivors and nonsurvivors, and the temporal trend of the radiographic-clinical features was analyzed. Results: The final cohort consisted of 93 patients: 68 survivors and 25 nonsurvivors. Nonsurvivors were significantly older than survivors. For both survivors and nonsurvivors, the chest CT scores were not different in the first period (0 -5 days) but diverged afterwards. The mortality rate of COVID-19 monotonously increased with chest CT scores, which positively correlated with the neutrophil-to-lymphocyte ratio, neutrophil percentage, D-dimer level, lactate dehydrogenase level and erythrocyte sedimentation rate, while negatively correlated with the lymphocyte percentage and lymphocyte count. Conclusions: Chest CT scores correlate well with...