ATRAID regulates the action of nitrogen-containing bisphosphonates on bone

作者：Lauren E. Surface, Damon T. Burrow, Jinmei Li, Jiwoong Park, Sandeep Kumar, Cheng Lyu, Niki Song, Zhou Yu, Abbhirami Rajagopal, Yangjin Bae, Brendan Lee, Steven Mumm, C. Charles Gu, Jonathan C. Baker, Mahshid Mohseni, Melissa Sum, Margaret Huskey, Shenghui Duan, Vinieth N. Bijanki, Roberto Civitelli, Michael J. Gardner, Chris M. McAndrew, William M. Ricci, Christina A. Gurnett, K Diemer, Fei Wan, Christina L. Costantino, Kristen Shannon, Noopur Raje, Thomas B. Dodson, Daniel A. Haber, Jan E. Carette, Malini Varadarajan, Thijn R. Brummelkamp, Kıvanç Birsoy, David M. Sabatini, Gabe Haller, Timothy R. Peterson · 发表于：Science Translational Medicine · 年份：2020 · DOI：10.1126/scitranslmed.aav9166 · 被引用次数：25 · 研究领域：Bone health and treatments、Radiopharmaceutical Chemistry and Applications、Boron Compounds in Chemistry

as conferring cellular hypersensitivity to N-BPs. Our work adds key insight into the mechanistic action of N-BPs and the processes that might underlie differential responsiveness to N-BPs in people.