Tumor-forming plasmacytoid dendritic cells in acute myelocytic leukemia: a report of three cases and literature review.

作者：Ping Wang, Yimei Feng, Xiaojuan Deng, Siheng Liu, Xing Qiang, Yang Gou, Jia Li, Wucheng Yang, Xiangui Peng, Xi Zhang · 发表于：PubMed · 年份：2017 · 被引用次数：13 · 研究领域：Chronic Lymphocytic Leukemia Research、Cutaneous lymphoproliferative disorders research、Lymphoma Diagnosis and Treatment

Plasmacytoid dendritic cells (PDCs), through their production of type I interferons (IFNs) and other pro-inflammatory cytokines, link the innate and adaptive immunity, and provide anti-viral resistance. It is reported PDCs accumulated in inflammatory and human neoplasms, including hematopoietic malignancies. To date, the clinical significance of tumor-forming PDCs (TF-PDCs) in AML is largely unknown. Here, we designed an integral scheme using flow cytometry, by which we accurately have detected the TF-PDCs in cases of AML. Combined the case characters and progress, we suggested that: TF-PDCs in AML maybe originate from the bone marrow mononuclear precursor cells, so it often associated with mononuclear line-related myeloid tumors; the accumulation of PDCs indicated highly aggressive tumor with poor progress and probably potential myelodysplasia or dysplasia.