The Brain’s Glymphatic System: Current Controversies

作者：Humberto Mestre, Yuki Mori, Maiken Nedergaard · 发表于：Trends in Neurosciences · 年份：2020 · DOI：10.1016/j.tins.2020.04.003 · 被引用次数：622 · 研究领域：Cerebrospinal fluid and hydrocephalus、Fetal and Pediatric Neurological Disorders、Spinal Dysraphism and Malformations

The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted that fluid is directionally transported within the central nervous system (CNS). Imaging studies, as well as manipulations of fluid transport, point to a key role of the glymphatic-lymphatic system in clearance of amyloid-β and other proteins. As such, the glymphatic-lymphatic system represents a new target in combating neurodegenerative diseases. Not unexpectedly, introduction of a new plumbing system in the brain has stirred controversies. This opinion article will highlight what we know about the brain's fluid transport systems, where experimental data are lacking, and what is still debated.