The obesity-induced adipokine sST2 exacerbates adipose T reg and ILC2 depletion and promotes insulin resistance

作者：Xu-Yun Zhao, Linkang Zhou, Zhimin Chen, Yewei Ji, Xiaoling Peng, Ling Qi, Siming Li, Jiandie D. Lin · 发表于：Science Advances · 年份：2020 · DOI：10.1126/sciadv.aay6191 · 被引用次数：76 · 研究领域：IL-33, ST2, and ILC Pathways、Immune Cell Function and Interaction、Adipokines, Inflammation, and Metabolic Diseases

/ILC2s, more pronounced adipose tissue inflammation and fibrosis, and impaired glucose homeostasis in mice. Mechanistically, Zbtb7b suppresses NF-κB activation in response to TNFα through destabilizing IκBα. These findings uncover an adipokine-immune signaling pathway that is engaged in obesity to drive the pathological changes of the immunometabolic landscape.