Cobalt-Catalyzed E -Selective Isomerization of Alkenes with a Phosphine-Amido-Oxazoline Ligand

作者：Hongmei Liu, Cheng Cai, Yanghao Ding, Jianhui Chen, Bosheng Liu, Yuanzhi Xia · 发表于：ACS Omega · 年份：2020 · DOI：10.1021/acsomega.0c00951 · 被引用次数：32 · 研究领域：Synthetic Organic Chemistry Methods、Catalytic C–H Functionalization Methods、Chemical Synthesis and Analysis

High Resolution Image Download MS PowerPoint Slide An efficient method to access ( E )-trisubstituted alkenes is reported via cobalt-catalyzed isomerization of 1,1-disubstituted alkenes using a phosphine-amido-oxazoline ligand. The reaction could also convert mono- and 1,2-disubstituted alkenes to ( E )-internal alkenes with benzylic selectivity. This protocol is atom-economy and operationally simple and uses readily available starting materials with good functional tolerance. This catalytic system could be scaled up to gram scale smoothly with a catalyst loading of 0.1 mol %.