Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerization

作者：Jaspreet Banga, Dinesh Srinivasan, Chia-Chi Sun, Cherrie D. Thompson, Francesca Milletti, Kuo‐Sen Huang, Shannon Hamilton, Su Song, Ann F. Hoffman, Yajuan Qin, Bharati Matta, Margaret LaPan, Qin Guo, Gang Lu, Dan Li, Hong Qian, David Bolin, Lena Liang, Charles Wartchow, Jin Qiu, Michelle Downing, Satwant K. Narula, Nader Fotouhi, Julie A. DeMartino, Seng‐Lai Tan, Gang Chen, Betsy Barnes · 发表于：Science Advances · 年份：2020 · DOI：10.1126/sciadv.aay1057 · 被引用次数：29 · 研究领域：Immunotherapy and Immune Responses、Immune Response and Inflammation、interferon and immune responses

)IRF5], with no effect on pIRF5 levels. These data support that IRF5-CPPs function downstream of phosphorylation. Together, data support the utility of IRF5-CPPs as novel tools to probe IRF5 activation and function in disease.