A human monoclonal antibody blocking SARS-CoV-2 infection

作者：Chunyan Wang, Wentao Li, Dubravka Drabek, Nisreen M.A. Okba, Rien van HAPEREN, Albert D. M. E. Osterhaus, Frank J. M. van Kuppeveld, Bart L. Haagmans, Frank G. Grosveld, Berend‐Jan Bosch · 发表于：Nature Communications · 年份：2020 · DOI：10.1038/s41467-020-16256-y · 被引用次数：1155 · 研究领域：SARS-CoV-2 and COVID-19 Research、vaccines and immunoinformatics approaches、Animal Virus Infections Studies

The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.