Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome.

作者：Yingqiang Du, Xin Gu, Haoyu Meng, Nan Aa, Shuiyuan Liu, Chengyi Peng, Yingbin Ge, Zhijian Yang · 发表于：PubMed · 年份：2018 · 被引用次数：58 · 研究领域：Inflammasome and immune disorders、Cardiac Fibrosis and Remodeling、Atherosclerosis and Cardiovascular Diseases

inflammation model to further clarify anti-inflammatory mechanisms of muscone. Muscone significantly downregulated the levels of LPS-induced inflammatory cytokines and inhibited NF-κB and NLRP3 inflammasome activation in BMDMs. Moreover, ROS and antioxidant indices in LPS-induced BMDMs were also ameliorated after muscone treatment. To sum up, our study found that muscone alleviated cardiac macrophage-mediated chronic inflammation by inhibiting NF-κB and NLRP3 inflammasome activation, thereby improving cardiac function in MI mice. Besides, the inhibitory effect of muscone on inflammation may be related to the scavenging of ROS. It is suggested that muscone may serve as a promising and effective drug for post-MI treatment.