Comprehensive Insights into the Catalytic Mechanism of Middle East Respiratory Syndrome 3C-Like Protease and Severe Acute Respiratory Syndrome 3C-Like Protease

作者：Hao Wang, Shuai He, Weilong Deng, Ying Zhang, Guobang Li, Jixue Sun, Wei Zhao, Yu Guo, Zheng Yin, Dongmei Li, Luqing Shang · 发表于：ACS Catalysis · 年份：2020 · DOI：10.1021/acscatal.0c00110 · 被引用次数：100 · 研究领域：Protein Structure and Dynamics、SARS-CoV-2 and COVID-19 Research、Computational Drug Discovery Methods

from SARS and MERS, conduct mutational studies to improve the catalytic activity by 8-fold, optimize existing inhibitors to improve the potency by 4-fold, and identify a potential allosteric site for inhibitor design. All such results reinforce each other to support the overall catalytic mechanism proposed herein.