Mechanisms of Toxicity and Cardiotoxicity of Alcohol Extract from Root, Stem and Leaf of Chloranthus Serratus.

作者：Shuping Sun, H X Li, X P Zhang, Yunfei Ma, Min Yang · 发表于：PubMed · 年份：2019 · DOI：10.12116/j.issn.1004-5619.2019.02.017 · 被引用次数：4 · 研究领域：Traditional Chinese Medicine Analysis、Neurological Disease Mechanisms and Treatments、Peroxisome Proliferator-Activated Receptors

ABSTRACT: <0.05）. The positive expression of ICAM-1 enhanced and the expression of HO-1 protein decreased in every group after the intervention of different extracts. The change trend was stem alcohol > leaf alcohol > root alcohol group. Conclusion The alcohol extract from the stem has the highest cardiotoxicity, followed by the leaf extract, and its mechanism of toxicity may be related to oxidative stress.