Exosomal miR-183-5p promotes angiogenesis in colorectal cancer by regulation of FOXO1

作者：Anquan Shang, Xuan Wang, Chenzheng Gu, Wenfang Liu, Junjun Sun, Bingjie Zeng, Chen Chen, Ping Ji, Junlu Wu, Wenqiang Quan, Yiwen Yao, Weiwei Wang, Zujun Sun, Dong Li · 发表于：Aging · 年份：2020 · DOI：10.18632/aging.103145 · 被引用次数：86 · 研究领域：Extracellular vesicles in disease、Circular RNAs in diseases、MicroRNA in disease regulation

experiments confirmed the tumor-promotive effects of CRC cell-derived exosomal miR-183-5p. Collectively, our study demonstrates that the CRC cell-derived exosomes overexpressing miR-183-5p aggravates CRC through the regulation of FOXO1. Exosomes overexpressing miR-183-5p might be a potential treatment biomarker for CRC.