Advances in the application of gold nanoparticles in bone tissue engineering

作者：Hongru Li, Su Pan, Peng Xia, Yuxin Chang, Chuan Fu, Weijian Kong, Ziyuan Yu, Kai Wang, Xiaoyu Yang, Zhiping Qi · 发表于：Journal of Biological Engineering · 年份：2020 · DOI：10.1186/s13036-020-00236-3 · 被引用次数：87 · 研究领域：Nanoparticle-Based Drug Delivery、Bone Tissue Engineering Materials、Advanced Nanomaterials in Catalysis

The materials used in bone tissue engineering (BTE) have been advancing with each passing day. With the continuous development of nanomedicine, gold nanoparticles (GNPs), which are easy to be synthesized and functionalized, have attracted increasing attention. Recent years have witnessed this amazing material, i.e., GNPs characterized with large surface area to volume ratio, biocompatibility, medical imaging property, hypotoxicity, translocation into the cells, high reactivity, and other properties, perform distinct functions in BTE. However, the low stability of GNPs in the biotic environment makes them in the requirements of modification or recombination before being used. After being combined with the advantages of other materials, the structures of GNPs have exhibited great potential in stem cells, scaffolds, delivery systems, medical imaging, and other aspects. This review will focus on the advances in the application of GNPs after modification or recombination with other materials to BTE.