CD31 and D2-40 Contribute to Peritoneal Metastasis of Colorectal Cancer by Promoting Epithelial-Mesenchymal Transition

作者：Xinqiang Zhu, Gang Zhou, Peng Ni, Xuetong Jiang, Hailong Huang, Jianqiang Wu, Xiaohong Shi, Xiaoling Jiang, Jianing Liu · 发表于：Gut and Liver · 年份：2020 · DOI：10.5009/gnl19407 · 被引用次数：24 · 研究领域：Cancer Cells and Metastasis、Gastric Cancer Management and Outcomes、Metastasis and carcinoma case studies

BACKGROUND/AIMS: Colorectal cancer (CRC) patients often exhibit peritoneal metastasis, which negatively impacts their prognosis. CD31 and D2-40 have recently been suggested to be predictors of breast cancer prognosis, but their role in colorectal peritoneal metastasis (CRPM) remains unknown. METHODS: , and peritoneal metastasis potential in a mouse model of CRPM were examined. RESULTS: . CONCLUSIONS: CD31 and D2-40 contribute to CRPM by promoting EMT and may serve as prognostic markers and therapeutic targets for CRC, particularly in patients with peritoneal metastasis.