Long non-coding RNA TUG1 promotes progression of oral squamous cell carcinoma through upregulating FMNL2 by sponging miR-219.

作者：Guangqi Yan, Xue Wang, Mingliang Yang, Li Lu, Qing Zhou · 发表于：PubMed · 年份：2017 · 被引用次数：34 · 研究领域：Cancer-related molecular mechanisms research、RNA modifications and cancer、MicroRNA in disease regulation

. Clinically, the expression of TUG1 and FMNL2 were increased, but miR-219 was decreased in primary tumors compared to non-tumor tissues. Both the upregulated TUG1, and FMNL2 and the downregulated miR-219 was associated with advanced stage of OSCC and poor overall survival. Notably, multivariate analyses confirmed that FMNL2 was an independent risk factor for OSCC. In conclusion, our data revealed that TUG1 confers oncogenic function in OSCC and TUG1/miR-219/FMNL2 axis may be a novel therapeutic strategy in this disease.