Prior therapies as prognostic factors of overall survival in metastatic castration-resistant prostate cancer patients treated with [177Lu]Lu-PSMA-617. A WARMTH multicenter study (the 617 trial)

作者：Hojjat Ahmadzadehfar, Kambiz Rahbar, Richard P. Baum, Robert Seifert, Katharina Kessel, Martin Bögemann, Harshad Kulkarni, Jingjing Zhang, Carolin Gerke, Rolf Fimmers, Clemens Kratochwil, Hendrik Rathke, Harun Ilhan, Johanna Maffey-Steffan, Mike Sathekge, Levent Kabasakal, Francisco O. García-Pérez, Kalevi Kairemo, Masha Maharaj, Diana Páez, Irene Virgolini · 发表于：European Journal of Nuclear Medicine and Molecular Imaging · 年份：2020 · DOI：10.1007/s00259-020-04797-9 · 被引用次数：129 · 研究领域：Prostate Cancer Treatment and Research、Radiopharmaceutical Chemistry and Applications、Prostate Cancer Diagnosis and Treatment

Abstract Introduction The impact of prior therapies, especially chemotherapy, on overall survival (OS) in patients with castration-resistant prostate cancer (CRPC) receiving [177Lu]Lu-PSMA-617 therapy has been the subject of controversy. Therefore, WARMTH decided to plan a multicenter retrospective analysis (the “617 trial”) to evaluate response rate and OS as well as the impact of prior therapies on OS in more than 300 patients treated with 177Lu-PSMA-617. Materials and methods The data of 631 metastatic CRPC (mCRPC) patients from 11 different clinics were evaluated. According to the inclusion and exclusion criteria, all patients had to have received at least abiraterone or enzalutamide prior to [177Lu]Lu-PSMA-617 therapy. The patients were divided into three groups: patients who had received prior chemotherapy, patients who avoided chemotherapy, and patients for whom a chemotherapy was contraindicated. Results The analysis included the data of 416 patients, with a median age of 71.9 years. At the time of analysis, 87 patients (20,9%) were still alive. A total of 53.6% of patients had received both abiraterone and enzalutamide; 75.5% and 26.4% had a history of chemotherapy with docetaxel and cabazitaxel, respectively. A total of 20.4% had had Ra-223. The median OS was 11.1 months. Prior chemotherapy, the existence of bone and liver metastases, as well as Eastern Cooperative Oncology Group (ECOG) status, were significant prognosticators of worse overall survival in both univa...