FOXO1 deficiency impairs proteostasis in aged T cells

作者：Jun Jin, Xuanying Li, Bin Hu, Chulwoo Kim, Wenqiang Cao, Huimin Zhang, Cornelia M. Weyand, Jörg J. Goronzy · 发表于：Science Advances · 年份：2020 · DOI：10.1126/sciadv.aba1808 · 被引用次数：55 · 研究领域：FOXO transcription factor regulation、Genetics, Aging, and Longevity in Model Organisms

T cells develop features reminiscent of senescent cells. They acquire an increased cell mass, preferentially differentiate into short-lived effector T cells, and secrete exosomes that harm cells in the local environment through the release of granzyme B.