Isolation of infectious SARS-CoV-2 from urine of a COVID-19 patient

作者：Jing Sun, Airu Zhu, Heying Li, Kui Cheng Zheng, Zhen Zhuang, Chen Zhao, Yongxia Shi, Zhaoyong Zhang, Si-bei Chen, Xuesong Liu, Jun Dai, Xiaobo Li, Shuxiang Huang, Xiaofang Huang, Ling Luo, Liyan Wen, Jianfen Zhuo, Yuming Li, Yuming Li, Yanqun Wang, Lu Zhang, Yanjun Zhang, Fang Li, Liqiang Feng, Xinwen Chen, Nanshan Zhong, Zifeng Yang, Jicheng Huang, Jincun Zhao, Yi-min Li, Yi-min Li · 发表于：Emerging Microbes & Infections · 年份：2020 · DOI：10.1080/22221751.2020.1760144 · 被引用次数：366 · 研究领域：SARS-CoV-2 and COVID-19 Research、COVID-19 Clinical Research Studies、SARS-CoV-2 detection and testing

SARS-CoV-2 caused a major outbreak of severe pneumonia (COVID-19) in humans. Viral RNA was detected in multiple organs in COVID-19 patients. However, infectious SARS-CoV-2 was only isolated from respiratory specimens. Here, infectious SARS-CoV-2 was successfully isolated from urine of a COVID-19 patient. The virus isolated could infect new susceptible cells and was recognized by its' own patient sera. Appropriate precautions should be taken to avoid transmission from urine.