TLR2/CXCR4 coassociation facilitatesChlamydia pneumoniaeinfection-induced atherosclerosis

作者：Guolin Miao, Xi Zhao, Beibei Wang, Lijun Zhang, Lijun Zhang, Guangyan Wang, Ningbo Zheng, Jingya Liu, Zhelong Xu, Lijun Zhang, Lijun Zhang · 发表于：American Journal of Physiology-Heart and Circulatory Physiology · 年份：2020 · DOI：10.1152/ajpheart.00011.2020 · 被引用次数：24 · 研究领域：Immune Response and Inflammation、Bacterial Infections and Vaccines、Streptococcal Infections and Treatments

Toll-like receptor 2 (TLR2) and C-X-C motif chemokine receptor 4 (CXCR4) have both been shown to be involved in atherosclerosis. We demonstrate for the first time the presence of TLR2/CXCR4 coassociation during C. pneumoniae infection-induced atherosclerosis. Amazingly, blocking of both TLR2 and CXCR4 significantly retards and even almost reverses this infection-induced atherosclerosis. Our work reveals new mechanisms about C. pneumoniae infection-induced atherosclerosis and identifies potential new therapeutic targets for the prevention and treatment of atherosclerosis.