Central nervous system involvement by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)

作者：Alberto Paniz‐Mondolfi, Clare Bryce, Zachary Grimes, Ronald E. Gordon, Jason Reidy, John A. Lednicky, Emilia Mia Sordillo, Mary Fowkes · 发表于：Journal of Medical Virology · 年份：2020 · DOI：10.1002/jmv.25915 · 被引用次数：1014 · 研究领域：Long-Term Effects of COVID-19、SARS-CoV-2 and COVID-19 Research、COVID-19 Clinical Research Studies

Neurologic sequelae can be devastating complications of respiratory viral infections. We report the presence of virus in neural and capillary endothelial cells in frontal lobe tissue obtained at postmortem examination from a patient infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Our observations of virus in neural tissue, in conjunction with clinical correlates of worsening neurologic symptoms, pave the way to a closer understanding of the pathogenic mechanisms underlying central nervous system involvement by SARS-CoV-2.