Long Noncoding RNA and Predictive Model To Improve Diagnosis of Clinically Diagnosed Pulmonary Tuberculosis

作者：Xuejiao Lina Hu, S. Matthew Liao, Hao Bai, Shubham Gupta, Yi Zhou, Juan Zhou, Lin Jiao, Lijuan Wu, Minjin Wang, Xuerong Chen, Yanhong Zhou, Xiaojun Lu, Ye Hu, Zhaolei Zhang, Binwu Ying · 发表于：Journal of Clinical Microbiology · 年份：2020 · DOI：10.1128/jcm.01973-19 · 被引用次数：36 · 研究领域：Mycobacterium research and diagnosis、Cancer-related molecular mechanisms research、Tuberculosis Research and Epidemiology

Clinically diagnosed pulmonary tuberculosis (PTB) patients lack microbiological evidence of Mycobacterium tuberculosis , and misdiagnosis or delayed diagnosis often occurs as a consequence. We investigated the potential of long noncoding RNAs (lncRNAs) and corresponding predictive models to diagnose these patients. We enrolled 1,764 subjects, including clinically diagnosed PTB patients, microbiologically confirmed PTB cases, non-TB disease controls, and healthy controls, in three cohorts (screening, selection, and validation).