The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

作者：Orit Rozenblatt–Rosen, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer Rood, Orr Ashenberg, Ethan G Cerami, Robert J. Coffey, Emek Demir, Li Ding, Edward D. Esplin, James M. Ford, Jeremy Goecks, Sharmistha Ghosh, Joe W. Gray, Justin Guinney, Sean E. Hanlon, Shannon K. Hughes, E. Shelley Hwang, Christine A. Iacobuzio–Donahue, Judit Jané‐Valbuena, Bruce Evan Johnson, Ken S. Lau, Tracy Lively, Sarah A. Mazzilli, Dana Pe’er, Sandro Santagata, Alex K. Shalek, Denis Schapiro, Michael Snyder, Peter Karl Sorger, Avrum E. Spira, Sudhir Srivastava, Kai Tan, Robert B. West, Elizabeth H. Williams, Denise R. Aberle, Samuel I. Achilefu, Foluso Olabisi Ademuyiwa, Andrew Adey, Rebecca Aft, Rachana Agarwal, Ruben A. Aguilar, Fatemeh Alikarami‬, Viola Allaj, Christopher Ian Amos, Robert A. Anders, Michael R. Angelo, Kristen Anton, Orr Ashenberg, Jon Christopher Aster, Özgün Babur, Amir Hossein Alizadeh Bahmani, Akshay Balsubramani, David Barrett, Jennifer Beane, Diane E. Bender, Kathrin Maria Bernt, Lynne D. Berry, Courtney B. Betts, Julie A. Bletz, Katie E. Blise, Adrienne Ann Boire, Genevieve Marie Boland, Alexander Borowsky, Kristopher R. Bosse, Matthew Joseph Bott, Ed Boyden, James D. Brooks, Raphael Bueno, Erik Ames Burlingame, Qiuyin Cai, Joshua David Campbell, Wagma Caravan, Ethan G Cerami, Hassan Chaı̈b, Joseph Minhow Chan, Young Hwan Chang, Deyali Chatterjee, Ojasvi Chaudhary, Alyce A. Chen, Bob Chen, Changya Chen, Chia‐Hui Chen, Feng Chen, Yuan Chen, Milan G. Chheda, Koei Chin, Roxanne Chiu, Shih‐Kai Chu, Rodrigo F. Chuaqui, Jaeyoung Chun, Luis Humberto Cisneros, Robert J. Coffey, Graham A. Colditz, Kristina Ann Cole, Natalie Bucheimer Collins, Kévin Contrepois, Lisa M. Coussens, Allison Creason, Daniel J. Crichton, Christina N. Curtis, Tanja M. Davidsen, Sherri R. Davies, Ino de Bruijn, Laura K. DelloStritto, Angelo De Marzo, Emek Demir, David Glenn DeNardo, Dinh Diep, Li Ding, Sharon J. Diskin, Xengie Doan, Julia L. Drewes, S. Dubinett, Michael A. Dyer, Jacklynn V. Egger, Jennifer R. Eng, Barbara E. Engelhardt, Graham Scott Erwin, Edward D. Esplin, Laura Esserman, Alex S. Felmeister, Heidi S. Feiler, Ryan Courtney Fields, Stephen Fisher, Keith T. Flaherty, Jennifer Flournoy, James M. Ford, Angelo Fortunato, Allison Frangieh, Jennifer L. Frye, Robert S. Fulton, Danielle Galipeau, Siting Gan, Jianjiong Gao, Long Gao, Peng Gao, Vianne Ran Gao, Tim Geiger, Ajit George, Gad A. Getz, Sharmistha Ghosh, Marios Giannakis, David L. Gibbs, William E. Gillanders, Jeremy Goecks, Simon Peter Goedegebuure, Alanna Gould, Kate H.C. Gowers, Joe W. Gray, William James Greenleaf, Jeremy S. Gresham, Jennifer L. Guerriero, Tuhin Kumar Guha, Alexander R. Guimarães, Justin Guinney, David A. Gutman, Nir Hacohen, Sean E. Hanlon, Casey R. Hansen, Olivier Harismendy, Kathleen A. Harris, Aaron N. Hata, Akimasa Hayashi, Cody N. Heiser, Karla E. Helvie, John M. Herndon, Gilliam Hirst, Frank Stephen Hodi, Travis J. Hollmann, Aaron M. Horning, James J.-D. Hsieh, Shannon Hughes, Won Jae Huh, Stephen P. Hunger, Shelley E. Hwang, Christine A. Iacobuzio–Donahue, Heba Ijaz, Benjamin Izar, Connor A. Jacobson, Sam M. Janes, Judit Jané‐Valbuena, Reyka G. Jayasinghe, Lihua Jiang, Brett Johnson, Bruce Evan Johnson, Tao Ju, Humam N. Kadara, Klaus H. Kaestner, Jacob A. Kagan, Lukas Kalinke, Robert L. Keith, Aziz Khan, Warren A. Kibbe, Albert H. Kim, Erika Kim, Junhyong Kim, Annette Kolodzie, Mateusz Kopytra, Eran Kotler, Robert Krueger, Kostyantyn Krysan, Anshul Kundaje, Uri Ladabaum, Blue B. Lake, Huy Lam, Rozelle Laquindanum, Ken S. Lau, Ashley M. Laughney, Hayan Lee, Marc E. Lenburg, Carina A. Leonard, Ignaty Leshchiner, Rochelle Levy, Jerry Li, Christine Guo Lian, Kian‐Huat Lim, Jia‐Ren Lin, Yiyun Lin, Qi Liu, Ruiyang Liu, Tracy Lively, William J.R. Longabaugh, Teri A. Longacre, Cynthia X. Ma, Mary Catherine Macedonia, Tyler Madison, Christopher A. Maher, Anirban Maitra, Netta Mäkinen, Danika Makowski, Carlo C. Maley, Zoltan Maliga, Diego Mallo, John M. Maris, Nick Markham, Jeffrey R. Marks, Daniel Martínez, R. Jay Mashl, Ignas Masilionais, Jennifer L. Mason, Joan Massagué, Pierre Pascal Massion, Marissa S. Mattar, Richard V. Mazurchuk, Linas Mažutis, Sarah A. Mazzilli, Eliot T. McKinley, Joshua F. McMichael, Daniel T. Merrick, Matthew M. Meyerson, Julia R. Miessner, Gordon Brent Mills, Meredith A. Mills, Suman Mondal, Motomi Mori, Yuriko Mori, Elizabeth Moses, Yaël P. Mossé, Jeremy L. Muhlich, Gëorge F. Murphy, Nicholas E. Navin, Tal Nawy, Michel A. Nederlof, Reid M. Ness, Stephanie A. Nevins, Milen Nikolov, Ajit J. Nirmal, Garry P. Nolan, Edward Novikov, Philipp Oberdoerffer, Brendan L. O’Connell, Michael David Offin, Stephen T. Oh, Anastasiya Olson, Alex Ooms, Miguel R. Ossandon, Kouros Owzar, Swapnil S Parmar, Tasleema Patel, Gary J. Patti, Dana Pe’er, Itsik Pe'er, Tao Peng, Daniel Persson, Marvin Petty, Hanspeter Pfister, Kornélia Polyák, Kamyar Esmaeili Pourfarhangi, Sidharth V. Puram, Qi Qiu, Àlvaro Quintanal-Villalonga, Arjun Raj, Marisol A Ramirez-Solano, Rumana Rashid, Ashley N. Reeb, Aviv Regev, Mary E. Reid, Adam Cain Resnick, Sheila M. Reynolds, Jessica L. Riesterer, Scott J. Rodig, Joseph T. Roland, Sonia M. Rosenfield, Asaf Rotem, Sudipta Singha Roy, Orit Rozenblatt–Rosen, Charles M. Rudin, Marc D. Ryser, Sandro Santagata, Maria Santi-Vicini, Kazuhito Sato, Denis Schapiro, Deborah Schrag, Nikolaus D. Schultz, Cynthia L. Sears, Rosalie C. Sears, Subrata Sen, Triparna Sen, Alex K. Shalek, Jeff Sheng, Quanhu Sheng, Kooresh Isaac Shoghi, Martha J. Shrubsole, Yu Shyr, Alexander B. Sibley, Kiara Siex, Alan J. Simmons, Dinah S. Singer, Shamilene Sivagnanam, Michal Slyper, Michael Snyder, Artem Sokolov, Sheng-Kwei Song, Peter Karl Sorger, Austin N. Southard-Smith, Avrum E. Spira, Sudhir Srivastava, Janet M. Stein, Phillip B. Storm, Elizabeth H. Stover, Siri H. Strand, Timothy Su, Damir Sudar, Ryan Joseph Sullivan, Lea F. Surrey, Mario L. Suvà, Kai Tan, Nadezhda V. Terekhanova, Luke Ternes, Lisa Thammavong, Guillaume Thibault, GEORGE V. THOMAS, Vésteinn Thórsson, Ellen Z. Todres, Linh My Tran, Madison Tyler, Yasin Uzun, Anil Vachani, Eliezer M. Van Allen, Simon Vandekar, Deborah J. Veis, Sébastien Vigneau, Arastoo Vossough, Angela Jae Waanders, Nikhil Wagle, Liang-Bo Wang, Michael C. Wendl, Robert B. West, Elizabeth H. Williams, Chi-Yun Wu, Hao Wu, Hung‐Yi Wu, Matthew A. Wyczalkowski, Yubin Xie, Xiaolu Yang, Clarence Yapp, Wenbao Yu, Yinyin Yuan, Dadong Zhang, Kun Zhang, Mianlei Zhang, Nancy R. Zhang, Yantian Zhang, Yanyan Zhao, Daniel Cui Zhou, Zilu Zhou, Houxiang Zhu, Qin Zhu, Xiangzhu Zhu, Yuankun Zhu, Xiaowei Zhuang · 发表于：Cell · 年份：2020 · DOI：10.1016/j.cell.2020.03.053 · 被引用次数：623 · 研究领域：Single-cell and spatial transcriptomics、Cell Image Analysis Techniques、Cancer Genomics and Diagnostics

Crucial transitions in cancer-including tumor initiation, local expansion, metastasis, and therapeutic resistance-involve complex interactions between cells within the dynamic tumor ecosystem. Transformative single-cell genomics technologies and spatial multiplex in situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution. The Human Tumor Atlas Network (HTAN), part of the National Cancer Institute (NCI) Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types. This effort complements both ongoing efforts to map healthy organs and previous large-scale cancer genomics approaches focused on bulk sequencing at a single point in time. Generating single-cell, multiparametric, longitudinal atlases and integrating them with clinical outcomes should help identify novel predictive biomarkers and features as well as therapeutically relevant cell types, cell states, and cellular interactions across transitions. The resulting tumor atlases should have a profound impact on our understanding of cancer biology and have the potential to improve cancer detection, prevention, and therapeutic discovery for better precision-medicine treatments of cancer patients and those at risk for cancer.