Studies on the Relation of the Kidney to Cardiovascular Disease.

作者：M. C. Winternitz, E. Mylon, L. L. Waters, R Katzenstein · 发表于：PubMed · 年份：1940 · 被引用次数：76 · 研究领域：Hormonal Regulation and Hypertension

During the past two years a large number of animals have been injected repeatedly and over long periods with kidney extracts known to induce marked vasopressor effects. These studies are the natural corollary of previously reported investigations in which similar extracts of the kidney were used with bilaterally nephrectomized dogs.4 It should be recalled that some of these extracts, specifically those that result from the simple treatment of minced kidney with saline, even when dialyzed and filtered, contain depressor as well as pressor agents, and that the former may act so promptly and be so potent that they completely mask the presence of the latter. The depressor substance is readily removable, however, and then agents responsible for raising the blood pressure are easily demonstrated. Animals injected with these extracts vary somewhat in their dayto-day reactions to the agents which lower and elevate blood pressure. When this is taken into consideration, and also when extracts are