Copper-catalyzed direct amination of benzylic hydrocarbons and inactive aliphatic alkanes with arylamines

作者：Hua Yao, Bo Xie, Xiaoyang Zhong, Shengzhou Jin, Sen Lin, Zhaohua Yan · 发表于：Organic & Biomolecular Chemistry · 年份：2020 · DOI：10.1039/d0ob00491j · 被引用次数：15 · 研究领域：Synthesis and Catalytic Reactions、Catalytic C–H Functionalization Methods、Asymmetric Hydrogenation and Catalysis

A new synthetic method toward direct C-N bond formation through saturated C-H amination of benzylic hydrocarbons and inactive aliphatic alkanes with primary aromatic amines under an inexpensive catalyst/oxidant (Cu/DTBP) system has been developed. Both aminopyridines and anilines could react smoothly with primary and secondary benzylic C-H substrates or cyclohexane to form the corresponding aromatic secondary amines in moderate to good yields. This protocol has the advantages of wide functional group tolerance and use of readily available raw materials.