Can people with asymptomatic or pre-symptomatic COVID-19 infect others: a systematic review of primary data

作者：Nelson Aguirre-Duarte · 发表于：medRxiv · 年份：2020 · DOI：10.1101/2020.04.08.20054023 · 被引用次数：21 · 研究领域：COVID-19 epidemiological studies、COVID-19 and Mental Health、SARS-CoV-2 and COVID-19 Research

Abstract Asymptomatic but infectious people have been reported in many infectious diseases. Asymptomatic and pre-symptomatic carriers would be a hidden reservoir of COVID-19. Aim This review identifies primary empirical evidence about the ability of asymptomatic carriers to infect others with COVID-19 pandemic and reflects on the implications for control measures. Methods A systematic review is followed by a narrative report and commentary inclusion criteria were: studies reporting primary data on asymptomatic or pre-symptomatic patients, who were considered to have passed on COVID-19 infection; and published in indexed journals or in peer review between January 1 and March 31, 2020. Results Nine articles reported on 83 asymptomatic or pre-symptomatic persons. Conclusions The evidence confirms COVID-19 transmission from people who were asymptomatic at the time. A series of implications for health service response are laid out.