SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride

作者：Qian Zhao, Zhiyuan Tian, Guoyu Zhou, Qiang Niu, Jingwen Chen, Pei Li, Lixin Dong, Tao Xia, Shun Zhang, Aiguo Wang · 发表于：Theranostics · 年份：2020 · DOI：10.7150/thno.42387 · 被引用次数：125 · 研究领域：Fluoride Effects and Removal、Anesthesia and Neurotoxicity Research、Bone and Dental Protein Studies

: Our data suggest the pivotal role of impaired mitochondrial biogenesis in developmental fluoride neurotoxicity and the underlying SIRT1 signaling dysfunction in such neurotoxic process, which emphasizes RSV as a potential therapeutic dietary agent for relieving developmental fluoride neurotoxicity.