Tumor-neuroglia interaction promotes pancreatic cancer metastasis

作者：Dan Su, Xiaofeng Guo, Leyi Huang, Huilin Ye, Zhiguo Li, Longfa Lin, Rufu Chen, Quanbo Zhou · 发表于：Theranostics · 年份：2020 · DOI：10.7150/thno.42440 · 被引用次数：79 · 研究领域：Cancer, Stress, Anesthesia, and Immune Response、Cancer Cells and Metastasis、Glioma Diagnosis and Treatment

: Schwann cells were extensively distributed in the PDAC tumor microenvironment and high level of intra-tumoral SC markers could serve as an independent prognostic factor for poor survival of patients with PDAC. The tumor-neuroglia interaction is indispensable for SCs to acquire a tumor-facilitating phenotype. Targeting the tumor-neuroglia interplay might be a promising strategy to treat PDAC.