Spread of SARS-CoV-2 in the Icelandic Population

作者：Daníel F. Guðbjartsson, Agnar Helgason, Hákon Jónsson, Ólafur Þ. Magnússon, Páll Melsted, Gudmundur L. Norddahl, Jona Saemundsdottir, Ásgeir Sigurðsson, Patrick Sulem, Arna B. Agustsdottir, Berglind Eiríksdottir, Rún Friðriksdóttir, Elisabet E Gardarsdottir, G. Georgsson, Olafia S. Gretarsdottir, Kjartan R. Guðmundsson, Thora R Gunnarsdottir, Arnaldur Gylfason, Hilma Hólm, Brynjar Ö. Jensson, Áslaug Jónasdóttir, Frosti Jónsson, Kamilla S. Josefsdottir, Þórður Kristjánsson, Droplaug N. Magnúsdóttir, Louise le Roux, Guðrún Sigmundsdóttir, Garðar Sveinbjörnsson, Kristin E. Sveinsdottir, Maney Sveinsdottir, Emil Aron Thorarensen, Bjarni Thorbjornsson, Arthur D. Love, Gísli Másson, Ingileif Jónsdóttir, Alma D. Möller, Þórólfur Guðnason, Karl G. Kristinsson, Unnur Þorsteinsdóttir, Kāri Stefánsson · 发表于：New England Journal of Medicine · 年份：2020 · DOI：10.1056/nejmoa2006100 · 被引用次数：1418 · 研究领域：SARS-CoV-2 detection and testing、COVID-19 epidemiological studies、SARS-CoV-2 and COVID-19 Research

BACKGROUND: During the current worldwide pandemic, coronavirus disease 2019 (Covid-19) was first diagnosed in Iceland at the end of February. However, data are limited on how SARS-CoV-2, the virus that causes Covid-19, enters and spreads in a population. METHODS: We targeted testing to persons living in Iceland who were at high risk for infection (mainly those who were symptomatic, had recently traveled to high-risk countries, or had contact with infected persons). We also carried out population screening using two strategies: issuing an open invitation to 10,797 persons and sending random invitations to 2283 persons. We sequenced SARS-CoV-2 from 643 samples. RESULTS: As of April 4, a total of 1221 of 9199 persons (13.3%) who were recruited for targeted testing had positive results for infection with SARS-CoV-2. Of those tested in the general population, 87 (0.8%) in the open-invitation screening and 13 (0.6%) in the random-population screening tested positive for the virus. In total, 6% of the population was screened. Most persons in the targeted-testing group who received positive tests early in the study had recently traveled internationally, in contrast to those who tested positive later in the study. Children under 10 years of age were less likely to receive a positive result than were persons 10 years of age or older, with percentages of 6.7% and 13.7%, respectively, for targeted testing; in the population screening, no child under 10 years of age had a positive result,...