Circulating miR-320a as a Predictive Biomarker for Left Ventricular Remodelling in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention

作者：Isabel Galeano-Otero, Raquel Del Toro, Agustín Guisado, Ignacio Díaz, Isabel Mayoral-González, Francisco J. Guerrero-Márquez, Encarnación Gutiérrez‐Carretero, Sara Casquero-Domínguez, Luis Salvador Diaz de la Llera, Gonzalo Barón‐Esquivias, Manuel Francisco Jiménez-Navarro, Tarik Smani, Antonio Ordóñez · 发表于：Journal of Clinical Medicine · 年份：2020 · DOI：10.3390/jcm9041051 · 被引用次数：28 · 研究领域：MicroRNA in disease regulation、Circular RNAs in diseases、Coronary Interventions and Diagnostics

Restoration of epicardial coronary blood flow, achieved by early reperfusion with primary percutaneous coronary intervention (PPCI), is the guideline recommended to treat patients with ST-segment-elevation myocardial infarction (STEMI). However, despite successful blood restoration, increasing numbers of patients develop left ventricular adverse remodelling (LVAR) and heart failure. Therefore, reliable prognostic biomarkers for LVAR in STEMI are urgently needed. Our aim was to investigate the role of circulating microRNAs (miRNAs) and their association with LVAR in STEMI patients following the PPCI procedure. We analysed the expression of circulating miRNAs in blood samples of 56 patients collected at admission and after revascularization (at 3, 6, 12 and 24 h). The associations between miRNAs and left ventricular end diastolic volumes at 6 months were estimated to detect LVAR. miRNAs were also analysed in samples isolated from peripheral blood mononuclear cells (PBMCs) and human myocardium of failing hearts. Kinetic analysis of miRNAs showed a fast time-dependent increase in miR-133a, miR-133b, miR-193b, miR-499, and miR-320a in STEMI patients compared to controls. Moreover, the expression of miR-29a, miR-29b, miR-324, miR-208, miR-423, miR-522, and miR-545 was differentially expressed even before PPCI in STEMI. Furthermore, the increase in circulating miR-320a and the decrease in its expression in PBMCs were significantly associated with LVAR and correlated with the express...