Comparison of structural characteristics and immunoregulatory activities of polysaccharides from four natural plants

作者：Mahepali Mahabati, Adila Aipire, Pengfei Yuan, Xiaoying Liu, Shanshan Cai, Alimu Aimaier, Dilinigeer Ziyayiding, Mayila Yasheng, Dilinazi Abudujilile, Jinyao Li · 发表于：Food and Agricultural Immunology · 年份：2020 · DOI：10.1080/09540105.2020.1743647 · 被引用次数：5 · 研究领域：Polysaccharides and Plant Cell Walls、Fungal Biology and Applications、Pharmacological Effects of Natural Compounds

Polysaccharides have various bioactivities including anti-tumour, antioxidant and immunoregulation, which are correlated with their structural characteristics. Here, four polysaccharides from Glycyrrhiza uralensis (GUPS), Pleurotus ferulae (PFPS), Triticum aestivum (TAPS) and Oryza sativa (OSPS) were purified to compare their structural characteristics and immunoregulatory activities. The data showed that TAPS, OSPS, GUPS and PFPS contained different monosaccharide components and had distinctly structural characteristics. All the four polysaccharides promoted the maturation of dendritic cells (DCs) through TLR4 with different activities. GUPS and PFPS also reduced the phagocytosis of DCs but not for TAPS and OSPS. Importantly, GUPS and PFPS enhanced the Th1 skewing immune response in mice without inflammation. TAPS and OSPS only showed weak immunostimulatory activity in vivo. The immunostimulatory activities of the four polysaccharides were ranked as PFPS = GUPS > TAPS > OSPS.