IL-9 and IL-9-producing cells in tumor immunity

作者：Jie Wan, Yinqiu Wu, Xiaoyun Ji, Lan Huang, Wei Cai, Zhaoliang Su, Shengjun Wang, Huaxi Xu · 发表于：Cell Communication and Signaling · 年份：2020 · DOI：10.1186/s12964-020-00538-5 · 被引用次数：83 · 研究领域：Immunotherapy and Immune Responses、Immune Cell Function and Interaction、T-cell and B-cell Immunology

Abstract Interleukin (IL)-9 belongs to the IL-2Rγc chain family and is a multifunctional cytokine that can regulate the function of many kinds of cells. It was originally identified as a growth factor of T cells and mast cells. In previous studies, IL-9 was mainly involved in the development of allergic diseases, autoimmune diseases and parasite infections. Recently, IL-9, as a double-edged sword in the development of cancers, has attracted extensive attention. Since T-helper 9 (Th9) cell-derived IL-9 was verified to play a powerful antitumor role in solid tumors, an increasing number of researchers have started to pay attention to the role of IL-9-skewed CD8 + T (Tc9) cells, mast cells and Vδ2 T cell-derived IL-9 in tumor immunity. Here, we review recent studies on IL-9 and several kinds of IL-9-producing cells in tumor immunity to provide useful insight into tumorigenesis and treatment. Graphical abstract