Mechanism of increased risk of insulin resistance in aging skeletal muscle

作者：Jian Shou, Peijie Chen, Wei-Hua Xiao · 发表于：Diabetology & Metabolic Syndrome · 年份：2020 · DOI：10.1186/s13098-020-0523-x · 被引用次数：284 · 研究领域：Nutrition and Health in Aging、Adipose Tissue and Metabolism、Muscle Physiology and Disorders

As age increases, the risk of developing type 2 diabetes increases, which is associated with senile skeletal muscle dysfunction. During skeletal muscle aging, mitochondrial dysfunction, intramyocellular lipid accumulation, increased inflammation, oxidative stress, modified activity of insulin sensitivity regulatory enzymes, endoplasmic reticulum stress, decreased autophagy, sarcopenia and over-activated renin-angiotensin system may occur. These changes can impair skeletal muscle insulin sensitivity and increase the risk of insulin resistance and type 2 diabetes during skeletal muscle aging. This review of the mechanism of the increased risk of insulin resistance during skeletal muscle aging will provide a more comprehensive explanation for the increased incidence of type 2 diabetes in elderly individuals, and will also provide a more comprehensive perspective for the prevention and treatment of type 2 diabetes in elderly populations.