Highly bioactive zeolitic imidazolate framework-8–capped nanotherapeutics for efficient reversal of reperfusion-induced injury in ischemic stroke

作者：Lizhen He, Guanning Huang, Hongxing Liu, Chengcheng Sang, Xinxin Liu, Tianfeng Chen · 发表于：Science Advances · 年份：2020 · DOI：10.1126/sciadv.aay9751 · 被引用次数：376 · 研究领域：Advanced Nanomaterials in Catalysis、Neuroinflammation and Neurodegeneration Mechanisms、Nanoplatforms for cancer theranostics

@ZIF-8 also suppresses inflammation- and immune response-induced injury by suppressing the activation of astrocytes and secretion of proinflammatory cytokines, thus achieving satisfactory prevention and treatment in neuroprotective therapy. This study also sheds light on the neuroprotective action mechanisms of ZIF-8-capped nanomedicine against reperfusion-induced injury in ischemic stroke.