Visible-Light-Driven Copper-Catalyzed C(sp3)–O Cross-Coupling of Benzylic Radicals with Phenols

作者：Xiaoye Yu, Jun Chen, Jun Chen, Hongwei Chen, Wen‐Jing Xiao, Jia‐Rong Chen, Jia‐Rong Chen · 发表于：Organic Letters · 年份：2020 · DOI：10.1021/acs.orglett.0c00532 · 被引用次数：50 · 研究领域：Radical Photochemical Reactions、Catalytic Cross-Coupling Reactions、Sulfur-Based Synthesis Techniques

)-O coupling of benzylic radicals with phenols is described for the first time. This operationally simple and robust process features mild conditions, broad scope, and high functional-group tolerance, enabling the construction of a diverse range of cyanoalkylated aryl ethers (33 examples). Key to this protocol is the dual role of copper salt that acts not only as a photosensitizer but also as a cross-coupling catalyst.